Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates
Yange Huang, Pui Ying Choy, Junya Wang, Man‐Kin Tse, Raymond Wai‐Yin Sun, Albert S. C. Chan, Fuk Yee Kwong
Abstract
A palladium-catalyzed C–N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)2 associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional group compatibility. This method provides an alternative synthetic pathway for accessing structurally diversified N,N-diarylhydrazines from simple and easily accessible coupling components.
Topics & Concepts
PhosphinePalladiumArylChemistryCatalysisCombinatorial chemistryCompatibility (geochemistry)Coupling reactionLigand (biochemistry)Functional groupOrganic chemistryMaterials sciencePolymerAlkylBiochemistryComposite materialReceptorCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis