Development of a small molecule-based two-photon photosensitizer for targeting cancer cells
Dong Joon Lee, Yu Cao, Vinayak Juvekar, Sauraj, Choong‐Kyun Noh, Sung Jae Shin, Zhihong Liu, Hwan Myung Kim
Abstract
biocompatibility. In cancer models such as three-dimensional spheroids and actual colon cancer tissues, BSe-B selectively induced ROS production and cell death under TP irradiation, demonstrating precise spatial control. These findings highlight the potential of BSe-B for imaging-guided PDT and its capability for micro treatment within tissues. Thus, BSe-B demonstrates robust TP-PDT capabilities, making it a promising dual-purpose tool for cancer diagnosis and treatment.
Topics & Concepts
PhotosensitizerMaterials scienceTwo-photon excitation microscopyMoleculePhotonNanotechnologySmall moleculeCancer cellBiophysicsCancer researchPhotochemistryCancerChemistryOpticsMedicineFluorescenceBiochemistryBiologyPhysicsOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotochromic and Fluorescence Chemistry