A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies
Shuang Chao, Xiukai Lv, Ning Ma, Ziyan Shen, Feiyu Zhang, Yuxin Pei, Zhichao Pei
Abstract
A supramolecular nanoprodrug based on the host-guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells. In vitro studies revealed that the Dox-loaded WP5G-Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.
Topics & Concepts
CurcuminChemistrySupramolecular chemistryPillarCombinatorial chemistryAnticancer drugStereochemistryDrugOrganic chemistryMoleculeBiochemistryPharmacologyStructural engineeringMedicineEngineeringSupramolecular Chemistry and ComplexesSupramolecular Self-Assembly in MaterialsBoron Compounds in Chemistry