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Unprecedented Reactivities of Highly Reactive Manganese(III)–Iodosylarene Porphyrins in Oxidation Reactions

Lina Zhang, Yong‐Min Lee, Mian Guo, Shunichi Fukuzumi, Wonwoo Nam

2020Journal of the American Chemical Society25 citationsDOI

Abstract

We report that Mn(III)-iodosylarene porphyrins, [MnIII(Porp)(sArIO)]+, are capable of activating the C–H bonds of hydrocarbons, including unactivated alkanes such as cyclohexane, with unprecedented reactivities, such as a low kinetic isotope effect, a saturation behavior of reaction rates, and no electronic effect of porphyrin ligands on the reactivities of [MnIII(Porp)(sArIO)]+. In oxygen atom transfer (OAT) reactions, the sulfoxidation of para-X-substituted thioanisoles by [MnIII(Porp)(sArIO)]+ affords a very unusual behavior in the Hammett plot with the saturation behavior of reaction rates and no electronic effect of porphyrin ligands on reactivities. The reactivities and mechanisms of [MnIII(Porp)(sArIO)]+ are then compared with those of the corresponding MnIV(Porp)(O) complex. The present study reports the first example of highly reactive Mn(III)–iodosylarene porphyrins with unprecedented reactivities in C–H bond activation and OAT reactions.

Topics & Concepts

ChemistryHammett equationManganeseCyclohexanePorphyrinPhotochemistryKinetic isotope effectReactivity (psychology)Saturation (graph theory)Medicinal chemistryReaction rate constantKineticsOrganic chemistryPathologyQuantum mechanicsMedicineCombinatoricsMathematicsDeuteriumPhysicsAlternative medicinePorphyrin and Phthalocyanine ChemistryMetal-Catalyzed Oxygenation MechanismsOxidative Organic Chemistry Reactions
Unprecedented Reactivities of Highly Reactive Manganese(III)–Iodosylarene Porphyrins in Oxidation Reactions | Litcius