ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit
Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez‐Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luís Vázquez
Abstract
lipid flippase, a first step towards the understanding of the essential physiological role of this transporter and towards its validation as a potential antimalarial drug target.
Topics & Concepts
FlippasePhosphatidylserinePhosphatidylethanolamineATPaseBiologyBiochemistryPhosphatidylinositolATP hydrolysisCell biologyATP-binding cassette transporterP-type ATPaseTransporterTranslocasePlasmodium falciparumPhospholipidMalariaEnzymeMembraneSignal transductionGenePhosphatidylcholineImmunologyChromosomal translocationDrug Transport and Resistance MechanismsMalaria Research and ControlHIV/AIDS drug development and treatment