Endothelial MAP2K1 mutations in arteriovenous malformation activate the RAS/MAPK pathway
Patrick Smits, Dennis J. Konczyk, Christopher L. Sudduth, Jeremy A. Goss, Arin K. Greene
Topics & Concepts
MAPK/ERK pathwayMutantTrametinibUmbilical veinMEK inhibitorPhosphorylationBiologyCancer researchCell biologyMutationVascular smooth muscleVascular malformationMedicineEndocrinologyGeneticsGeneIn vitroSmooth muscleRadiologyVascular Malformations Diagnosis and TreatmentVascular Malformations and HemangiomasVascular Anomalies and Treatments