Rapid and sensitive LC-MS/MS method for the enantioanalysis of verapamil in rat plasma using superficially porous silica isopropyl-cyclofructan 6 chiral stationary phase after SPE: Application to a stereoselective pharmacokinetic study
Mohamed Hefnawy, Abdulrhman Al-Majed, Haitham AlRabiah, Nasser Algrain, Mostafa Mohammed, Yousef A. Bin Jardan
Topics & Concepts
ChemistryChromatographyEnantiomerSelected reaction monitoringPharmacokineticsStereoselectivityIsopropylMass spectrometrySolid phase extractionAmmonium formateTandem mass spectrometryLiquid chromatography–mass spectrometryStereochemistryOrganic chemistryInternal medicineMedicineCatalysisAnalytical Chemistry and ChromatographyAntibiotics Pharmacokinetics and EfficacyAnalytical chemistry methods development