A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway
Fei Lin, Guanglin Zhang, Xihan Yang, Mengshi Wang, Ruixuan Wang, Meiqi Wan, Jinyu Wang, Bo Wu, Tingxu Yan, Ying Jia
Topics & Concepts
Colorectal cancerPharmacologyApoptosisPI3K/AKT/mTOR pathwayMedicineMechanism (biology)CancerTraditional medicineChemistryInternal medicineBiochemistryPhilosophyEpistemologyFerroptosis and cancer prognosisCancer-related gene regulationFerrocene Chemistry and Applications