Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease among a Cognitively Healthy Population-Based Cohort
Emma Casey, Zhenjiang Li, Donghai Liang, Stefanie Ebelt, Allan I. Levey, James J. Lah, Thomas S. Wingo, Anke Hüls
Abstract
BACKGROUND: ) on early predictors of future disease risk. OBJECTIVES: and cerebrospinal fluid (CSF) biomarkers of AD. METHODS: and CSF biomarker concentrations, considering continuous and dichotomous (dichotomized at clinical cutoffs) outcomes, were estimated with multiple linear/logistic regression, respectively, controlling for potential confounders (age, gender, race, ethnicity, body mass index, and neighborhood socioeconomic status). RESULTS: levels were mainly null. CONCLUSION: , which suggests an accumulation of amyloid plaques in the brain and an increased risk of developing AD. https://doi.org/10.1289/EHP13503.
Topics & Concepts
Interquartile rangeMedicineBiomarkerConfidence intervalConfoundingBody mass indexCohortPopulationCohort studyEpidemiologyRotterdam StudyEnvironmental healthInhalation exposureInternal medicineBiologyToxicityBiochemistryAir Quality and Health ImpactsClimate Change and Health ImpactsNoise Effects and Management