Copper-Catalyzed Photoinduced Enantioselective Dual Carbofunctionalization of Alkenes
Yajing Zhang, Youwen Sun, Bin Chen, Meichen Xu, Chen Li, Dayong Zhang, Guozhu Zhang
Abstract
A photoinduced, copper-catalyzed, highly enantioselective dual alkylation/arylation and alkynylation of alkene is reported. A single chiral copper(I) complex serves to enable photoredox catalysis and induce enantioselectivity during the reaction. This reaction couples three different components under mild reaction conditions, exhibits a broad substrate scope, and provides facile access to chiral propargylic systems, including those featuring valuable fluorinated substituents.
Topics & Concepts
Enantioselective synthesisChemistryAlkynylationCatalysisCopperAlkeneCombinatorial chemistrySubstrate (aquarium)AlkylationSynergistic catalysisPhotochemistryOrganic chemistryGeologyOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions