AIE + ESIPT activity-based NIR Cu<sup>2+</sup> sensor with dye participated binding strategy
Jie Jiang, Haifeng Sun, Yanlei Hu, Gang Lü, Jiwei Cui, Jingcheng Hao
Abstract
A novel activity-based Cu2+ fluorescent probe featuring multidentate binding sites was synthesized. It functions through chelation with Cu2+, which in turn specifically triggers hydrolysis of the probe to release a near-infrared emission with AIE + ESIPT properties. The probe was found to be capable of ratiometric imaging of Cu2+ in living HeLa cells.
Topics & Concepts
FluorescenceChemistryChelationDenticityPhotochemistryHydrolysisAggregation-induced emissionNuclear chemistryInorganic chemistryMetalOrganic chemistryOpticsPhysicsMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques