Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery
Gayathri R. Ediriweera, Joshua D. Simpson, Adrian V. Fuchs, T.K. Venkatachalam, Matthias Van De Walle, Christopher B. Howard, Stephen M. Mahler, James P. Blinco, Nicholas L. Fletcher, Zachary H. Houston, Craig A. Bell, Kristofer J. Thurecht
Abstract
There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile <italic>in vivo</italic>, as well as reducing side-effects for an increased standard of care.
Topics & Concepts
Modular designBioorthogonal chemistryDrug deliveryCancer therapyNanotechnologyComputer scienceChemistryKey (lock)Combinatorial chemistryCancerMedicineMaterials scienceClick chemistryInternal medicineProgramming languageComputer securityClick Chemistry and ApplicationsChemical Synthesis and AnalysisAdvanced biosensing and bioanalysis techniques