Bridging Cancer and Cardiovascular Health: A Comprehensive Review of Cardiotoxicity in Modern Oncology
Anjali Rajpoot, Veena Sharma
Abstract
Abstract As survival rates for cancer patients improve due to advancements in treatment modalities, there is an increasing prevalence of cardiovascular complications, necessitating a comprehensive understanding of this intersection. This review aims to elucidate the intricate relationship between cancer and cardiovascular disease, highlighting the growing concern of cardiovascular toxicity associated with cancer therapies. It explores various cancer treatments, including chemotherapy, targeted therapies, and radiation, and their associated cardiovascular risks, such as heart failure and ischemic heart disease. In addition, it discusses the importance of proactive cardiovascular risk assessments and ongoing monitoring in cancer patients to mitigate adverse outcomes. Strategies for prevention and management, including lifestyle modifications and pharmacologic interventions, are also examined to support the cardiovascular health of cancer survivors. Unlike previous reviews, this work integrates insights from multidisciplinary collaborations, emphasizing underexplored mechanisms of cardiovascular toxicity and the role of innovative monitoring tools. It also highlights emerging therapeutic strategies tailored to mitigate these risks, providing a forward-looking perspective in this critical area of research. The need for a collaborative method that includes oncologists, cardiologists, and primary care providers is emphasized to ensure integrated care that addresses both cancer treatment and cardiovascular health. This review serves as a critical resource for healthcare professionals seeking to improve the long-term outcomes for cancer survivors by recognizing and managing cardiovascular risks.