Catalytic asymmetric transformation of nitrones and allenes to dihydropyridoindoles <i>via</i> chiral <i>N</i>,<i>N</i>′-dioxide/cobalt(<scp>ii</scp>) catalysis
Mohuizi Liu, Lihua Xie, Liuzhen Hou, Lili Lin, Xiaoming Feng
Abstract
-aryl nitrones with allenes, giving a variety of chiral dihydropyridoindoles in moderate to good yields with excellent dr and ee values. Mechanistic studies support a [3+2] cycloaddition/[3,3]-rearrangement/retro-Mannich process.
Topics & Concepts
CatalysisCobaltChemistryTransformation (genetics)Combinatorial chemistryOrganic chemistryBiochemistryGeneAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions