BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol
Dongmei Wang, Quan Yuan, Shuwen Liu, Pu Zhao, Liang Chen, Yilu Ma, Sanqiang Li, Xiaoying Zhu, Xueqin Hao, Jian Shi, Hua Fan
Topics & Concepts
InflammasomePyroptosisSIRT3SOD2ChemistryReactive oxygen speciesOxidative stressHippocampal formationAIM2Cell biologyCaspase 1PharmacologyNeuroscienceImmunologyMedicineSirtuinBiologyInflammationBiochemistrySuperoxide dismutaseAcetylationGeneHeme Oxygenase-1 and Carbon MonoxideInflammasome and immune disordersEicosanoids and Hypertension Pharmacology