Challenges in exploring and manipulating the human skin microbiome
Manon Boxberger, Valérie Cenizo, Nadim Cassir, Bernard La Scola
Abstract
The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation. Video abstract.
Topics & Concepts
MicrobiomeBiologyHuman skinMicrobial ecologyHuman healthEcologyBioinformaticsBacteriaMedicineGeneticsEnvironmental healthDermatology and Skin DiseasesSkin Protection and AgingNail Diseases and Treatments