A European‐Japanese study on peach allergy: <scp>IgE</scp> to Pru p 7 associates with severity
E. J. J. Kallen, Alma Revers, Montserrat Fernández‐Rivas, Riccardo Asero, Barbara Ballmer‐Weber, Laura Barreales, Simona Bělohlávková, F. de Blay, Michael Clausen, R. Dubakiene, Motohiro Ebisawa, Cristina Fernández, Philipp Fritsche, Yuma Fukutomi, Davíð Gíslason, Karin Hoffmann‐Sommergruber, Monika Jędrzejczak-Czechowicz, André C. Knulst, Marek L. Kowalski, Tanya Kralimarkova, Jonas Lidholm, Carl M. Metzler, E. N. Clare Mills, Nikolaos G. Papadopoulos, Todor A. Popov, Ashok Purohit, Isabel Reig, Suranjith L. Seneviratne, A. Sinaniotis, Masami Takei, Serge A. Versteeg, A. E. Vassilopoulou, Stefan Vieths, Paco M J Welsing, Aeilko H. Zwinderman, Thuy‐My Le, Ronald van Ree
Abstract
BACKGROUND: Pru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity. METHODS: In twelve European (EuroPrevall project) and one Japanese outpatient clinic, a standardized clinical evaluation was conducted in 1231 patients who reported symptoms to peach and/or were sensitized to peach. Specific IgE against Pru p 1, 2, 3, 4 and 7 and against Cup s 7 was measured in 474 of them. Univariable and multivariable Lasso regression was applied to identify combinations of parameters predicting severity. RESULTS: Sensitization to Pru p 3 dominated in Southern Europe but was also quite common in Northern and Central Europe. Sensitization to Pru p 7 was low and variable in the European centers but very dominant in Japan. Severity could be predicted by a model combining age of onset of peach allergy, probable mugwort, Parietaria pollen and latex allergy, and sensitization to Japanese cedar pollen, Pru p 4 and Pru p 7 which resulted in an AUC of 0.73 (95% CI 0.73-0.74). Pru p 3 tended to be a risk factor in South Europe only. CONCLUSIONS: Pru p 7 was confirmed as a significant risk factor for severe peach allergy in Europe and Japan. Combining outcomes from clinical and demographic background with serology resulted in a model that could better predict severity than CRD alone.