Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue
Lars M. Mattison, Atul Verma, Khaldoun G. Tarakji, Tobias Reichlin, Gerhard Hindricks, Kevin L. Sack, Birce Önal, Megan Schmidt, Damijan Miklavčič, Daniel C. Sigg
Abstract
Abstract Introduction Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed field ablation (PFA) is a field‐based ablation technology for which limited evidence on the impact of contact force on lesion size is available. Methods Porcine hearts ( n = 6) were perfused using a modified Langendorff set‐up. A prototype focal PFA catheter attached to a force gauge was held perpendicular to the epicardium and lowered until contact was made. Contact force was recorded during each PFA delivery. Matured lesions were cross‐sectioned, stained, and the lesion dimensions measured. Results A total of 82 lesions were evaluated with contact forces between 1.3 and 48.6 g. Mean lesion depth was 4.8 ± 0.9 mm (standard deviation), mean lesion width was 9.1 ± 1.3 mm, and mean lesion volume was 217.0 ± 96.6 mm 3 . Linear regression curves showed an increase of only 0.01 mm in depth (depth = 0.01 × contact force + 4.41, R 2 = 0.05), 0.03 mm in width (width = 0.03 × contact force + 8.26, R 2 = 0.13) for each additional gram of contact force, and 2.20 mm 3 in volume (volume = 2.20 × contact force + 162, R 2 = 0.10). Conclusion Increasing contact force using a bipolar, biphasic focal PFA system has minimal effects on acute lesion dimensions in an isolated porcine heart model and achieving tissue contact is more important than the force with which that contact is made.