Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review
Sandeep Singh, P Geetha, R. Ramajayam
Abstract
The scaffold-based drug design has been widely used in new drug discovery. Biphenyl and its analog scaffold are found in many drugs and naturally occurring compounds. To date an array of synthetic methodologies have been introduced to access biphenyl analogs with good yield. Biphenyl scaffolds have shown wide range of biological activities such as anti-inflammatory, antihypertensive, treatment of CNS disorders, anti-cancer, anti-HIV, etc. Also, the importance of biphenyl atropisomers is discussed. This review aims to highlight the evidence of biphenyl motif as a privileged scaffold in various natural products and anticancer agents.
Topics & Concepts
BiphenylScaffoldChemistryAtropisomerDrug discoveryCombinatorial chemistryNanotechnologyComputational biologyStereochemistryBiologyOrganic chemistryBiochemistryComputer scienceMaterials scienceDatabaseCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality SynthesisSynthesis of heterocyclic compounds