Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma
Henrik Carlsson, Akshai Parakkal Sreenivasan, Ida Erngren, Anders Larsson, Kim Kultima
Abstract
metabolites, and two were diglyceride lipids (DG 24:6;O). The results demonstrate the potential of combining targeted and untargeted approaches to increase the coverage of compounds detected with a single method. This methodology is well suited for exposomics to detect previously unknown associations between environmental contaminants and endogenous compounds that may be important for human health.
Topics & Concepts
Human plasmaContaminationEnvironmental chemistryChromatographyMass spectrometryChemistryBiologyEcologyVitamin D Research StudiesHealth, Environment, Cognitive AgingEffects and risks of endocrine disrupting chemicals