‘In-water’, nickel-catalyzed mild preparation of allylic amines employing alcohols: application to ‘all-water’ synthesis of pharmaceuticals
Gargi Nikhil Vaidya, Ramesh Hiralal Choudhary, Mithilesh Nagpure, Shyam Kumar Lokhande, Pooja Rana, Dinesh Kumar
Abstract
Reported here is a nanomicelle-enabled, ‘in-water’, nickel-catalyzed allylic amination reaction using allylic alcohols under mild conditions (in the absence of additives/bases/activators).
Topics & Concepts
Allylic rearrangementCatalysisChemistryNickelOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis