Iron-catalysed alkene and heteroarene H/D exchange by reversible protonation of iron-hydride intermediates
Luke Britton, Jamie H. Docherty, Jan Sklyaruk, Jessica Cooney, Gary S. Nichol, Andrew P. Dominey, Stephen P. Thomas
Abstract
O as the deuterium source, and uses only bench-stable reagents, including the iron(ii) pre-catalyst. Further, a new mechanism of iron-hydride formation is reported in which β-hydride elimination from an alcohol generates the iron hydride. The ability to produce, isolate and characterise the organometallic products arising from C-H activation presents a basis for future discovery and development.
Topics & Concepts
AlkeneProtonationChemistryHydrideMedicinal chemistryOrganic chemistryHydrogenCatalysisIonChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisEpigenetics and DNA Methylation