Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings
Linda Solstrand Dahlberg, Ovidiu Lungu, Julien Doyon
Abstract
The present findings suggest that one of the main cerebellar implications in PD is linked to cognitive functioning. The negative association between UPDRS scores and activation in regions implicated in motor functioning indicate that there is less involvement of these areas as the disease severity increases. In contrast, the lack of correlation with disease duration seems to indicate that the cerebellar activity may be a compensatory mechanism to the dysfunctional basal ganglia, where certain sub-regions of the cerebellum are employed to cope with motor demands. Yet future longitudinal studies are needed to fully address this possibility.
Topics & Concepts
NeuroscienceCerebellumParkinson's diseaseMeta-analysisBasal gangliaNeurodegenerationPsychologyMovement disordersNeuroimagingSupplementary motor areaMotor symptomsFunctional neuroimagingMotor skillDiseasePhysical medicine and rehabilitationMedicineFunctional magnetic resonance imagingPathologyCentral nervous systemVestibular and auditory disordersNeurological disorders and treatmentsParkinson's Disease Mechanisms and Treatments