Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy
Michael J. Toth, Thomas B. Voigt, Timothy W. Tourville, Shannon M. Prior, Blas A. Guigni, Axel V. Schlosberg, Isaac Smith, Taylor J. Forest, Peter A. Kaufman, Marie Wood, Hibba tul Rehman, Kim Dittus
Abstract
This is the first study to evaluate whether neuromuscular electrical stimulation (NMES) can be used as an exercise surrogate to improve skeletal muscle fiber size or function in cancer patients receiving treatment. We show that NMES promoted muscle fiber hypertrophy and fiber type shifts but had minimal effects on single-fiber contractility and reduced subsarcolemmal mitochondria.
Topics & Concepts
ContractilityStimulationMedicineSkeletal muscleMuscle hypertrophyBreast cancerMuscle fibreInternal medicineCancerCardiologyEndocrinologyCancer survivorship and careCancer-related cognitive impairment studiesLymphatic System and Diseases