Targeted therapy of atherosclerosis by pH-sensitive hyaluronic acid nanoparticles co-delivering all-trans retinal and rapamycin
Nihad Cheraga, Zheng Ye, Mingjie Xu, Lin Zou, Ningxiang Sun, Hang Yue, Congjia Shan, Zhongzhou Yang, Lijuan Chen, Ning‐Ping Huang
Abstract
A smart nanoplatform based on hyaluronic acid was developed for targeted atherosclerosis combination therapy, which effectively attenuated the progression of the plaque by simultaneously reducing inflammation and oxidative stress at the aortic lesion.
Topics & Concepts
Hyaluronic acidInflammationReactive oxygen speciesChemistryInternalizationIn vitroPharmacologyOxidative stressAntioxidantBiochemistryCancer researchReceptorMedicineImmunologyAnatomyAtherosclerosis and Cardiovascular DiseasesRetinal Diseases and TreatmentsRetinal and Optic Conditions