CD45RO<sup>-</sup>CD8<sup>+</sup> T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis
Wen‐Jie Zhou, Jie Zhang, Feng Xie, Jiang‐Nan Wu, Jiang‐Feng Ye, Jian Wang, Ke Wu, Ming‐Qing Li
Abstract
T cell-released exosomes in UCEC development, and provides a potential therapeutic strategy for UCEC patients with aberrant ERβ/miR-765/PLP2/Notch signaling axis.
Topics & Concepts
Cancer researchCD8microRNAMicrovesiclesEstrogen receptorEstrogenBiologyBreast cancerImmunologyCancerMedicineInternal medicineImmune systemEndocrinologyGeneBiochemistryReproductive System and PregnancyCircular RNAs in diseasesEndometrial and Cervical Cancer Treatments