An Electrochemical Route for Special Oxidative Ring‐Opening of Indoles
Hong Qin, Zhao Yang, Zhen Zhang, Chengkou Liu, Wei He, Zheng Fang, Kai Guo
Abstract
A novel electrochemical protocol for the oxidative cleavage of indoles has been developed, which offers a simple way to access synthetically useful anthranilic acid derivatives. In undivided cells, a wide variety of indoles and alcohol compounds are examined to afford amide ester aromatics without using extra oxidants and stoichiometric metal catalysts, which avoids the formation of undesired by-products and exhibits high atom economy. The products we described in this perspective represent a synthetic intermediate in numerous drug molecules and industrial chemical reagents and remarkably show potential application in the future.
Topics & Concepts
Combinatorial chemistryChemistryAtom economyElectrochemistryOxidative phosphorylationAnthranilic acidRing (chemistry)CatalysisStoichiometryAmideMoleculeReagentOxidative cleavageOrganic chemistryPhysical chemistryBiochemistryElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions