AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
David Goertsen, Nicholas C. Flytzanis, Nick Goeden, Miguel R. Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y. Ip, James Pickel, Viviana Gradinaru
Topics & Concepts
MarmosetTransgeneCallithrixBiologyCapsidGenetic enhancementGene deliveryNeuroscienceTropismGenetically modified mouseAdeno-associated virusCentral nervous systemGeneVirologyVector (molecular biology)VirusGeneticsRecombinant DNAPaleontologyVirus-based gene therapy researchRNA Interference and Gene DeliveryCRISPR and Genetic Engineering