Discovery of novel non-nucleoside inhibitors with high potency and selectivity for DNA methyltransferase 3A
Jie Yu, Xin Chai, Jinping Pang, Zhe Wang, Hong Zhao, Tianli Xie, Lei Xu, Rong Sheng, Dan Li, Su Zeng, Tingjun Hou, Yu Kang
Topics & Concepts
ChemistryMethyltransferaseDNMT1Drug discoveryIC50EpigeneticsCytotoxicityDNA methyltransferaseBiochemistryPharmacologyIn vitroDNAGeneMethylationBiologyEpigenetics and DNA MethylationCancer-related gene regulationRNA modifications and cancer