Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX
Harshavardhan Bhuktar, Sharda Shukla, Kumar Reddy Kakularam, Srikanth Battu, Manupati Srikanth, Susmita Srivastava, Raghavender Medishetti, Pooja Ram, P.C. Jagadish, Mahaboobkhan Rasool, Sandipan Chakraborty, Nooruddin Khan, Pallu Reddanna, Srinivas Oruganti, Manojit Pal
Topics & Concepts
ChemistryArylArachidonate 5-lipoxygenaseLipoxygenaseQuinolineIn silicoDocking (animal)StereochemistryArachidonic acidEnzymeCombinatorial chemistryBiochemistryOrganic chemistryNursingAlkylGeneMedicineBioactive Compounds and Antitumor AgentsSynthesis and Biological EvaluationSynthesis and biological activity