C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α
Wenzhong Zheng, Kexin Wang, Yachen Wu, Yan Ge, Chi Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen
Abstract
In summary, these data reveal that C9orf72 modulates translation initiation, the UPR and SG formation, which have implications for understanding ALS/FTD pathogenesis.
Topics & Concepts
C9orf72Stress granuleHaploinsufficiencyUnfolded protein responseCell biologyBiologyEukaryotic translationTranslation (biology)Integrated stress responseTrinucleotide repeat expansionGeneticsEndoplasmic reticulumPhenotypeGeneMessenger RNAAlleleAmyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative DiseasesEndoplasmic Reticulum Stress and Disease