Efficacy and Safety of Corticosteroid Regimens for the Treatment of Hospitalized COVID-19 Patients: A meta-analysis
Fangwen Zhou, Jiawen Deng, Kiyan Heybati, Qi Zuo, Saif Ali, Wenteng Hou, Chi Yi Wong, Harikrishnaa Ba Ramaraju, Oswin Chang, Thanansayan Dhivagaran, Zachary Silver
Abstract
Aim: To evaluate the efficacy and safety of corticosteroids for treating hospitalized COVID-19 patients. Materials & methods: Efficacy outcomes included time to negative SARS-CoV-2 tests, length of stay, duration and incidence of intensive unit care stay, incidence of mortality and duration and incidence of mechanical ventilation. Safety outcomes included the incidence of adverse events and severe adverse events, incidence of hyperglycemia and incidence of nosocomial infections. Results: Ninety-five randomized controlled trials (RCTs) and observational studies (n = 42,205) were included. Corticosteroids were associated with increased length of stay (based on RCT only), increased time to negative tests, decreased length of mechanical ventilation and increased odds of hyperglycemia. Conclusion: Corticosteroids should be considered in patients requiring mechanical ventilation, and glycemic monitoring may be needed when administering corticosteroids.