Antiviral Peptides Targeting the Helicase Activity of Enterovirus Nonstructural Protein 2C
Yuan Fang, Chang Wang, Chong Wang, Ruyi Yang, Peng Bai, Xueyi Zhang, Jing Kong, Lei Yin, Yang Qiu, Xi Zhou
Abstract
Furthermore, we demonstrate that the strategy of targeting the 2C helicase activity can be used for other relevant enteroviruses, including coxsackievirus B3 and echovirus 11. In summary, our findings provide compelling evidence that the designed peptides targeting the helicase activity of 2C could be broad-spectrum antivirals for enteroviruses.
Topics & Concepts
BiologyEchovirusCoxsackievirusEnterovirusVirologyPicornaviridaeRNAHelicaseEnterovirus 71RNA Helicase AVirusGeneticsGeneViral Infections and Immunology ResearchViral gastroenteritis research and epidemiologyAnimal Disease Management and Epidemiology