Immunological drivers of amyotrophic lateral sclerosis
Tania F. Gendron, Leonard Petrucelli
Abstract
Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex genetic and environmental factors, is associated with neuroinflammation. Preclinical and clinical studies support immune system involvement in ALS pathogenesis, thereby spurring investigations into potential pathogenic mechanisms, immune response biomarkers, and ALS therapeutics.
Topics & Concepts
Amyotrophic lateral sclerosisNeuroinflammationImmune systemPathogenesisMedicineNeuroscienceMotor neuronDiseaseImmunologyBiologyPathologyAmyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments