Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis
Mohamed A. Tammam, Florbela Pereira, Omnia Aly, Mohamed Sebak, Yasser Diab, Aldoushy Mahdy, Amr El‐Demerdash
Abstract
-transferase (GST) and Cu-Zn human superoxide dismutase (Cu-ZnSOD) enzymes. Although the major role in the detoxification of foreign chemicals and toxic metabolites of GST and SOD enzymes is known, there is a lack of knowledge about the mode of action of the hepatoprotective process and those of the targets involved. The present study investigated the multiple interactions of a series of marine steroids with the GST and SOD enzymes, in order to reveal insights into the process of hepatoprotection.
Topics & Concepts
ChemistryEnzymePharmacologyGlutathioneFibrosisSuperoxide dismutaseBiochemistryBiologyPathologyMedicineLiver physiology and pathologyEnzyme function and inhibitionDrug-Induced Hepatotoxicity and Protection