The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency
Xue Shao, Haruki Uojima, Taeang Arai, Yuji Ogawa, Toru Setsu, Masanori Atsukawa, Yoshihiro Furuichi, Yoshitaka Arase, Kazue Horio, Hisashi Hidaka, Takahide Nakazawa, Makoto Kako, Tatehiro Kagawa, Katsuhiko Iwakiri, Atsushi Nakajima, Shuji Terai, Yasuhito Tanaka, Wasaburo Koizumi
Abstract
<b><i>Background:</i></b> Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce. <b><i>Objective:</i></b> This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations. <b><i>Methods:</i></b> Patients with LC caused by virus (<i>n</i> = 157), alcohol (<i>n</i> = 104), nonalcoholic fatty liver disease (NAFLD) (<i>n</i> = 106), or autoimmune disease (<i>n</i> = 33) and without LC (<i>n</i> = 128) were enrolled. LC was composed of the presence and absence of complications, such as variceal bleeding, hepatic ascites, and hepatic encephalopathy. To assess the role of the PNPLA3 polymorphism, odds ratio (OR) for the rs738409 variant was calculated for the patients between (i) with LC and without LC in the entire cohort and (ii) the presence and absence of complications in the patients with LC. <b><i>Results:</i></b> There was a significant difference among the patients without LC and those with alcohol, NAFLD-related LC in the frequency of G alleles (<i>p</i> &#x3c; 0.001, both). According to complications of LC, the OR for NAFLD-related cirrhosis significantly increased in the presence of the two mutated alleles (OR = 3.165; <i>p</i> = 0.046) when the wild type was used as the reference. However, there were no significant risks for the complications in the virus and alcohol-related cirrhosis unless there was a presence of G alleles. <b><i>Conclusion:</i></b> The PNPLA3 polymorphism was associated with the risk of NAFLD-related LC and its complications.