Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery
Tarun Patel, Nilanjan Adhikari, Sk. Abdul Amin, Swati Biswas, Tarun Jha, Balaram Ghosh
Abstract
Mechanisms of how SMDCs work. Small molecule drugs are conjugated with the targeted ligand using pH sensitive linkers which allow the drug molecule to get released at lower lysosomal pH. It helps to accumulate the chemotherapeutic agents to be localized in the tumor environment upon cleaving of the pH-labile bonds.
Topics & Concepts
ChemistryConjugateSmall moleculeDrugAnticancer drugDrug discoveryCombinatorial chemistryConjugated systemMoleculeLigand (biochemistry)PharmacologyStereochemistryBiochemistryOrganic chemistryReceptorPolymerMedicineMathematical analysisMathematicsClick Chemistry and ApplicationsCancer therapeutics and mechanismsProtein Degradation and Inhibitors