Using <i>Wolbachia</i> to Eliminate Dengue: Will the Virus Fight Back?
Kathryn Edenborough, Heather A. Flores, Cameron P. Simmons, Johanna E. Fraser
Abstract
Recent field trials have demonstrated that dengue incidence can be substantially reduced by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquito populations. This strategy relies on Wolbachia reducing the susceptibility of Ae. aegypti to disseminated infection by positive-sense RNA viruses like dengue.
Topics & Concepts
WolbachiaBiologyDengue feverVirologyDengue virusAedes aegyptiVirusHost (biology)GeneticsEcologyLarvaInsect symbiosis and bacterial influencesMosquito-borne diseases and controlInsect and Pesticide Research