A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression

Ishita Tandon, Alan E. Woessner, Laís Ferreira, Christine Shamblin, Gustavo Vaca-Diez, Amanda Walls, Patrick Kuczwara, Alexis P. Applequist, Denise Fabiano do Nascimento, Swastika Tandon, Jin-Woo Kim, Manuel K. Rausch, Tomasz A. Timek, Muralidhar Padala, Michael Kinter, Dennis Province, Stephanie D. Byrum, Kyle P. Quinn, Kartik Balachandran