Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors
Seok Jong Kang, Jung Wuk Lee, Jiho Song, Ji Won Park, Jaeyul Choi, Kwee Hyun Suh, Kyung Hoon Min
Abstract
of 27 nM. It showed a reversible reaction with β-mercaptoethanol, which supports its potential as a reversible covalent inhibitor.
Topics & Concepts
ImidazopyridineChemistryCovalent bondMoietyKinaseCysteineStereochemistryBiochemistryCombinatorial chemistryEnzymeOrganic chemistryNF-κB Signaling PathwaysInflammatory mediators and NSAID effectsSynthesis and biological activity