Colicins of Escherichia coli Lead to Resistance against the Diarrhea-Causing Pathogen Enterotoxigenic E. coli in Pigs
Leli Wang, Yu‐Wei Wu, Juan Xu, Qiuyun Huang, Ying Zhao, Dong Sheng, Xuxiang Wang, Xiaoni Cao, Chunni Wang, Anqi Wu, Diao Zhou, Cang Chen, Huansheng Yang, Jianzhong Li, Papadimitriou Konstantinos, Qiang Tu, Gaihua Zhang, Jia Yin
Abstract
This study revealed the heterogeneity of E. coli strains from pigs, including two strains studied by both in silico and wet experiments in detail and 14 strains studied by bioinformatics analysis. E. coli Y18J may improve the adaptability of pigs toward disease resistance through the production of colicins B and M. Our findings could shed light on the pathogenic and harmless roles of E. coli in modern animal husbandry, leading to a better understanding of intestinal-microbe–pathogen interactions in the course of evolution.