Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

Paul D. Donohoue, Martin Pačesa, Elaine K. Lau, Bastien Vidal, Matthew J. Irby, David B. Nyer, Tomer Rotstein, Lynda Banh, Mckenzi S. Toh, Jason Gibson, Bryan Kohrs, Kevin Baek, Arthur L.G. Owen, Euan M. Slorach, Megan van Overbeek, Christopher K. Fuller, Andrew P. May, Martin Jínek, Peter Cameron