Tumor Microenvironment-Activated Degradable Multifunctional Nanoreactor for Synergistic Cancer Therapy and Glucose SERS Feedback
Dan Sun, Guohua Qi, Kongshuo Ma, Xiaozhang Qu, Weiqing Xu, Shuping Xu, Yongdong Jin
Abstract
ions, all of which work together to inhibit tumor growth. The AgNPs@MBN as SERS nanoprobe reads out glucose concentration noninvasively in tumor to achieve instant feedback of therapeutic progression. This work proposes a promising example of using enzyme-encapsulated biomineralized MOFs as an effective anticarcinogen for clinical applications.
Topics & Concepts
NanoreactorGlucose oxidaseNanocarriersTumor microenvironmentChemistryNanotechnologyIn vivoNanoparticleBiophysicsBiochemistryCatalysisCancer researchMaterials scienceEnzymeBiologyTumor cellsBiotechnologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery