Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
Jacob H. Murray, David R. W. Hodgson, AnnMarie C. O’Donoghue
Abstract
Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis.
Topics & Concepts
BiocatalysisOrganocatalysisCofactorChemistryScope (computer science)Combinatorial chemistryBiochemical engineeringCatalysisOrganic chemistryEnzymeEnantioselective synthesisReaction mechanismComputer scienceEngineeringProgramming languageEnzyme Catalysis and ImmobilizationCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis