Targeted Therapy and Mechanisms of Drug Resistance in Breast Cancer
Briana Kinnel, Santosh Kumar Singh, Gabriela Oprea‐Ilies, Rajesh Singh
Abstract
Breast cancer is the most common cause of cancer-related death in women worldwide. Multidrug resistance (MDR) has been a large hurdle in reducing BC death rates. The drug resistance mechanisms include increased drug efflux, enhanced DNA repair, senescence escape, epigenetic alterations, tumor heterogeneity, tumor microenvironment (TME), and the epithelial-to-mesenchymal transition (EMT), which make it challenging to overcome. This review aims to explain the mechanisms of resistance in BC further, identify viable drug targets, and elucidate how those targets relate to the progression of BC and drug resistance.
Topics & Concepts
Drug resistanceBreast cancerEpigeneticsDrugTumor microenvironmentMultiple drug resistanceMedicineCancerEffluxCancer researchBioinformaticsPharmacologyBiologyInternal medicineGeneticsGeneAdvanced Breast Cancer TherapiesCancer-related Molecular PathwaysCancer Cells and Metastasis