Novel <i>N</i> -methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks
John N. Philoppes, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, Mohamed Sebak, Mostafa A. Darwish, Phoebe F. Lamie
Abstract
. Finally, a molecular modelling study and pharmacokinetic properties were obtained using different computational methods.
Topics & Concepts
ChemistryBiological activityAntimicrobialDPPHAntibacterial activityEnzymePharmacologyAntioxidantBiochemistryMinimum inhibitory concentrationIn vitroBacteriaBiologyOrganic chemistryGeneticsSynthesis and Biological EvaluationSynthesis and biological activityBioactive Compounds and Antitumor Agents