Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile
Salah A. Abdel‐Aziz, Ehab S. Taher, Ping Lan, Gihan F. Asaad, Hesham A. M. Gomaa, Nawal El‐Koussi, Bahaa G. M. Youssif
Topics & Concepts
ChemistryMeloxicamPharmacologyThiazoleErlotinibIn vivoPyrimidineTyrosine kinaseDocking (animal)StereochemistryBiochemistryEpidermal growth factor receptorMedicineReceptorNursingBiologyBiotechnologyInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis of β-Lactam Compounds