ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr
Shoucheng Du, John J. Alvarado, Thomas E. Wales, Jamie A. Moroco, John R. Engen, Thomas E. Smithgall
Topics & Concepts
AutophosphorylationProto-oncogene tyrosine-protein kinase SrcAllosteric regulationProtein kinase domainSH3 domainLinkerMyeloid leukemiaChemistryKinaseActive siteBinding siteBiochemistryDocking (animal)SH2 domainCell biologyBiologyEnzymeCancer researchProtein kinase AMutantMedicineNursingOperating systemGeneComputer scienceProtein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionChronic Myeloid Leukemia Treatments