Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer
Elena Catanzaro, Nibal Betari, José M. Arencibia, Serena Montanari, Claudia Sissi, Angela De Simone, Ivano Vassura, Alan Santini, Vincenza Andrisano, Vincenzo Tumiatti, Marco De Vivo, Dmitri V. Krysko, Marco Rocchi, Carmela Fimognari, Andrea Milelli
Topics & Concepts
ChemistryEtoposideCamptothecinQuinazolineNatural productLead compoundTopoisomeraseTopoisomerase inhibitorPharmacologyDrug discoveryDrugCancerCancer cellCombinatorial chemistryStereochemistryIn vitroBiochemistryChemotherapyMedicineSurgeryInternal medicineCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsSynthesis and Biological Evaluation