Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling
Kayoko Kawashima, Hiroyasu Ogawa, Shingo Komura, Toshinobu Ishihara, Yu Yamaguchi, Haruhiko Akiyama, Kazu Matsumoto
Topics & Concepts
Hereditary multiple exostosesCartilageChondrocyteCartilage oligomeric matrix proteinConditional gene knockoutBone morphogenetic proteinEndocrinologyCTGFBone morphogenetic protein 2Genetically modified mouseChemistryInternal medicineCell biologyPathologyBiologyTransgeneMedicineOsteoarthritisOsteochondromaAnatomyGrowth factorBiochemistryPhenotypeGeneAlternative medicineIn vitroReceptorOsteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchLiver physiology and pathology